WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for the enriched GO category are listed in this table. For each GO category, the first row lists its sub-root (biological process, molecular function, or cellular component), category name, and corresponding GO ID.
The second row lists the following statistics:
Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:biological process       Name:Wnt receptor signaling pathway       ID:GO:0016055
C=304; O=6; E=0.66; R=9.02; rawP=4.40e-05; adjP=0.0158
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000139174 NA PRICKLE1 prickle homolog 1 (Drosophila) 144165 ENSG00000139174
2  ENSG00000135272 NA MDFIC MyoD family inhibitor domain containing 29969 ENSG00000135272
3  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
4  ENSG00000143816 NA WNT9A wingless-type MMTV integration site family, member 9A 7483 ENSG00000143816
5  ENSG00000109062 NA SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 9368 ENSG00000109062
6  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:biological process       Name:primary neural tube formation       ID:GO:0014020
C=76; O=3; E=0.17; R=18.05; rawP=0.0006; adjP=0.0158
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000139174 NA PRICKLE1 prickle homolog 1 (Drosophila) 144165 ENSG00000139174
2  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
3  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:biological process       Name:skeletal system morphogenesis       ID:GO:0048705
C=179; O=4; E=0.39; R=10.22; rawP=0.0006; adjP=0.0158
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
2  ENSG00000143816 NA WNT9A wingless-type MMTV integration site family, member 9A 7483 ENSG00000143816
3  ENSG00000112280 NA COL9A1 collagen, type IX, alpha 1 1297 ENSG00000112280
4  ENSG00000156427 NA FGF18 fibroblast growth factor 18 8817 ENSG00000156427


Database:biological process       Name:cellular response to vitamin D       ID:GO:0071305
C=12; O=2; E=0.03; R=76.20; rawP=0.0003; adjP=0.0158
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
2  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:biological process       Name:regulation of Wnt receptor signaling pathway       ID:GO:0030111
C=183; O=4; E=0.40; R=9.99; rawP=0.0006; adjP=0.0158
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000139174 NA PRICKLE1 prickle homolog 1 (Drosophila) 144165 ENSG00000139174
2  ENSG00000135272 NA MDFIC MyoD family inhibitor domain containing 29969 ENSG00000135272
3  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
4  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:biological process       Name:neural tube closure       ID:GO:0001843
C=71; O=3; E=0.16; R=19.32; rawP=0.0005; adjP=0.0158
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000139174 NA PRICKLE1 prickle homolog 1 (Drosophila) 144165 ENSG00000139174
2  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
3  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:biological process       Name:negative regulation of canonical Wnt receptor signaling pathway       ID:GO:0090090
C=77; O=3; E=0.17; R=17.81; rawP=0.0006; adjP=0.0158
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000139174 NA PRICKLE1 prickle homolog 1 (Drosophila) 144165 ENSG00000139174
2  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
3  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:biological process       Name:cellular response to nutrient       ID:GO:0031670
C=74; O=3; E=0.16; R=18.53; rawP=0.0006; adjP=0.0158
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
2  ENSG00000143816 NA WNT9A wingless-type MMTV integration site family, member 9A 7483 ENSG00000143816
3  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:biological process       Name:negative regulation of cell communication       ID:GO:0010648
C=685; O=7; E=1.50; R=4.67; rawP=0.0006; adjP=0.0158
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000139174 NA PRICKLE1 prickle homolog 1 (Drosophila) 144165 ENSG00000139174
2  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
3  ENSG00000114737 NA CISH cytokine inducible SH2-containing protein 1154 ENSG00000114737
4  ENSG00000107295 NA SH3GL2 SH3-domain GRB2-like 2 6456 ENSG00000107295
5  ENSG00000109062 NA SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 9368 ENSG00000109062
6  ENSG00000120833 NA SOCS2 suppressor of cytokine signaling 2 8835 ENSG00000120833
7  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:biological process       Name:cellular response to vitamin       ID:GO:0071295
C=63; O=3; E=0.14; R=21.77; rawP=0.0003; adjP=0.0158
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
2  ENSG00000143816 NA WNT9A wingless-type MMTV integration site family, member 9A 7483 ENSG00000143816
3  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:molecular function       Name:inward rectifier potassium channel activity       ID:GO:0005242
C=20; O=2; E=0.04; R=49.30; rawP=0.0007; adjP=0.0189
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000120457 NA KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 3762 ENSG00000120457
2  ENSG00000099337 NA KCNK6 potassium channel, subfamily K, member 6 9424 ENSG00000099337


Database:molecular function       Name:Wnt-activated receptor activity       ID:GO:0042813
C=21; O=2; E=0.04; R=46.96; rawP=0.0008; adjP=0.0189
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
2  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:molecular function       Name:PDZ domain binding       ID:GO:0030165
C=89; O=3; E=0.18; R=16.62; rawP=0.0008; adjP=0.0189
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
2  ENSG00000109062 NA SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 9368 ENSG00000109062
3  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:molecular function       Name:Wnt-protein binding       ID:GO:0017147
C=28; O=2; E=0.06; R=35.22; rawP=0.0015; adjP=0.0266
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
2  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:molecular function       Name:protein binding       ID:GO:0005515
C=7337; O=23; E=14.88; R=1.55; rawP=0.0027; adjP=0.0319
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163297 NA ANTXR2 anthrax toxin receptor 2 118429 ENSG00000163297
2  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
3  ENSG00000143816 NA WNT9A wingless-type MMTV integration site family, member 9A 7483 ENSG00000143816
4  ENSG00000120833 NA SOCS2 suppressor of cytokine signaling 2 8835 ENSG00000120833
5  ENSG00000166689 NA PLEKHA7 pleckstrin homology domain containing, family A member 7 144100 ENSG00000166689
6  ENSG00000139174 NA PRICKLE1 prickle homolog 1 (Drosophila) 144165 ENSG00000139174
7  ENSG00000213523 NA SRA1 steroid receptor RNA activator 1 10011 ENSG00000213523
8  ENSG00000134775 NA FHOD3 formin homology 2 domain containing 3 80206 ENSG00000134775
9  ENSG00000147180 NA ZNF711 zinc finger protein 711 7552 ENSG00000147180
10  ENSG00000105204 NA DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 9149 ENSG00000105204
11  ENSG00000120457 NA KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 3762 ENSG00000120457
12  ENSG00000107295 NA SH3GL2 SH3-domain GRB2-like 2 6456 ENSG00000107295
13  ENSG00000109062 NA SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 9368 ENSG00000109062
14  ENSG00000156427 NA FGF18 fibroblast growth factor 18 8817 ENSG00000156427
15  ENSG00000170743 NA SYT9 synaptotagmin IX 143425 ENSG00000170743
16  ENSG00000143740 NA SNAP47 synaptosomal-associated protein, 47kDa 116841 ENSG00000143740
17  ENSG00000135272 NA MDFIC MyoD family inhibitor domain containing 29969 ENSG00000135272
18  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
19  ENSG00000175390 NA EIF3F eukaryotic translation initiation factor 3, subunit F 8665 ENSG00000175390
20  ENSG00000184349 NA EFNA5 ephrin-A5 1946 ENSG00000184349
21  ENSG00000243056 NA EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 8637 ENSG00000243056
22  ENSG00000164674 NA SYTL3 synaptotagmin-like 3 94120 ENSG00000164674
23  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:molecular function       Name:receptor binding       ID:GO:0005102
C=1211; O=8; E=2.46; R=3.26; rawP=0.0023; adjP=0.0319
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
2  ENSG00000184349 NA EFNA5 ephrin-A5 1946 ENSG00000184349
3  ENSG00000143816 NA WNT9A wingless-type MMTV integration site family, member 9A 7483 ENSG00000143816
4  ENSG00000109062 NA SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 9368 ENSG00000109062
5  ENSG00000213523 NA SRA1 steroid receptor RNA activator 1 10011 ENSG00000213523
6  ENSG00000156427 NA FGF18 fibroblast growth factor 18 8817 ENSG00000156427
7  ENSG00000120833 NA SOCS2 suppressor of cytokine signaling 2 8835 ENSG00000120833
8  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:molecular function       Name:G-protein coupled receptor binding       ID:GO:0001664
C=199; O=3; E=0.40; R=7.43; rawP=0.0075; adjP=0.0761
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
2  ENSG00000143816 NA WNT9A wingless-type MMTV integration site family, member 9A 7483 ENSG00000143816
3  ENSG00000109062 NA SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 9368 ENSG00000109062


Database:molecular function       Name:voltage-gated potassium channel activity       ID:GO:0005249
C=78; O=2; E=0.16; R=12.64; rawP=0.0109; adjP=0.0860
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000120457 NA KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 3762 ENSG00000120457
2  ENSG00000099337 NA KCNK6 potassium channel, subfamily K, member 6 9424 ENSG00000099337


Database:molecular function       Name:extracellular matrix structural constituent       ID:GO:0005201
C=78; O=2; E=0.16; R=12.64; rawP=0.0109; adjP=0.0860
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000143816 NA WNT9A wingless-type MMTV integration site family, member 9A 7483 ENSG00000143816
2  ENSG00000112280 NA COL9A1 collagen, type IX, alpha 1 1297 ENSG00000112280


Database:molecular function       Name:growth factor receptor binding       ID:GO:0070851
C=98; O=2; E=0.20; R=10.06; rawP=0.0168; adjP=0.1193
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000109062 NA SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 9368 ENSG00000109062
2  ENSG00000156427 NA FGF18 fibroblast growth factor 18 8817 ENSG00000156427


Database:cellular component       Name:collagen       ID:GO:0005581
C=89; O=3; E=0.17; R=17.96; rawP=0.0006; adjP=0.0237
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000186417 NA GLDN gliomedin 342035 ENSG00000186417
2  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
3  ENSG00000112280 NA COL9A1 collagen, type IX, alpha 1 1297 ENSG00000112280


Database:cellular component       Name:proteinaceous extracellular matrix       ID:GO:0005578
C=360; O=5; E=0.68; R=7.40; rawP=0.0005; adjP=0.0237
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
2  ENSG00000186417 NA GLDN gliomedin 342035 ENSG00000186417
3  ENSG00000143816 NA WNT9A wingless-type MMTV integration site family, member 9A 7483 ENSG00000143816
4  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
5  ENSG00000112280 NA COL9A1 collagen, type IX, alpha 1 1297 ENSG00000112280


Database:cellular component       Name:extracellular matrix       ID:GO:0031012
C=426; O=5; E=0.80; R=6.25; rawP=0.0011; adjP=0.0290
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
2  ENSG00000186417 NA GLDN gliomedin 342035 ENSG00000186417
3  ENSG00000143816 NA WNT9A wingless-type MMTV integration site family, member 9A 7483 ENSG00000143816
4  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
5  ENSG00000112280 NA COL9A1 collagen, type IX, alpha 1 1297 ENSG00000112280


Database:cellular component       Name:cell surface       ID:GO:0009986
C=495; O=5; E=0.93; R=5.38; rawP=0.0021; adjP=0.0415
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000184349 NA EFNA5 ephrin-A5 1946 ENSG00000184349
2  ENSG00000120457 NA KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 3762 ENSG00000120457
3  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
4  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
5  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240


Database:cellular component       Name:extracellular matrix part       ID:GO:0044420
C=185; O=3; E=0.35; R=8.64; rawP=0.0049; adjP=0.0774
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000186417 NA GLDN gliomedin 342035 ENSG00000186417
2  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
3  ENSG00000112280 NA COL9A1 collagen, type IX, alpha 1 1297 ENSG00000112280


Database:cellular component       Name:voltage-gated potassium channel complex       ID:GO:0008076
C=70; O=2; E=0.13; R=15.23; rawP=0.0076; adjP=0.0858
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000120457 NA KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 3762 ENSG00000120457
2  ENSG00000099337 NA KCNK6 potassium channel, subfamily K, member 6 9424 ENSG00000099337


Database:cellular component       Name:potassium channel complex       ID:GO:0034705
C=70; O=2; E=0.13; R=15.23; rawP=0.0076; adjP=0.0858
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000120457 NA KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 3762 ENSG00000120457
2  ENSG00000099337 NA KCNK6 potassium channel, subfamily K, member 6 9424 ENSG00000099337


Database:cellular component       Name:endomembrane system       ID:GO:0012505
C=1771; O=8; E=3.32; R=2.41; rawP=0.0144; adjP=0.1193
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163297 NA ANTXR2 anthrax toxin receptor 2 118429 ENSG00000163297
2  ENSG00000107295 NA SH3GL2 SH3-domain GRB2-like 2 6456 ENSG00000107295
3  ENSG00000109062 NA SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 9368 ENSG00000109062
4  ENSG00000170743 NA SYT9 synaptotagmin IX 143425 ENSG00000170743
5  ENSG00000143740 NA SNAP47 synaptosomal-associated protein, 47kDa 116841 ENSG00000143740
6  ENSG00000139174 NA PRICKLE1 prickle homolog 1 (Drosophila) 144165 ENSG00000139174
7  ENSG00000180957 NA PITPNB phosphatidylinositol transfer protein, beta 23760 ENSG00000180957
8  ENSG00000164674 NA SYTL3 synaptotagmin-like 3 94120 ENSG00000164674


Database:cellular component       Name:extracellular region part       ID:GO:0044421
C=1099; O=6; E=2.06; R=2.91; rawP=0.0151; adjP=0.1193
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104332 NA SFRP1 secreted frizzled-related protein 1 6422 ENSG00000104332
2  ENSG00000186417 NA GLDN gliomedin 342035 ENSG00000186417
3  ENSG00000143816 NA WNT9A wingless-type MMTV integration site family, member 9A 7483 ENSG00000143816
4  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
5  ENSG00000112280 NA COL9A1 collagen, type IX, alpha 1 1297 ENSG00000112280
6  ENSG00000156427 NA FGF18 fibroblast growth factor 18 8817 ENSG00000156427


Database:cellular component       Name:cell leading edge       ID:GO:0031252
C=257; O=3; E=0.48; R=6.22; rawP=0.0122; adjP=0.1193
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000109062 NA SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 9368 ENSG00000109062
2  ENSG00000213523 NA SRA1 steroid receptor RNA activator 1 10011 ENSG00000213523
3  ENSG00000157240 NA FZD1 frizzled family receptor 1 8321 ENSG00000157240




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).